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Interferons establish an antiviral state through the induction of hundreds of interferon-stimulated genes (ISGs).The mechanisms and viral specificities for most ISGs remain incompletely understood.To enable high-throughput interrogation of ISG antiviral functions in pooled genetic screens while read more mitigating potentially confounding effects o
Living cells often need to measure chemical concentrations that vary in time, yet how accurately they can do so is poorly understood.Here, we present a theory that fully specifies, without any adjustable parameters, the optimal design of a canonical sensing system in terms of two elementary design principles: (1) there exists an optimal integration
Ring spot, caused by the fungus Leptosphariea sacchari, is a disease of sugarcane read more that has been known to occur in Florida for over 80 years.Ring spot usually affects only the older leaves, and therefore is considered a minor disease.However, correctly identifying the disease in the field can help to reduce unnecessary chemical sprays.This
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